Team Withdrawals: Kingsteignton Athletic, Roselands, SGT Police Reserves, Totnes & Dartington, Watcombe Wanderers
DFL South & West Division 2021/22
| Pos | Club | P | W | D | L | F | A | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Teignmouth | 20 | 18 | 0 | 2 | 101 | 20 | 81 | 54 |
| 2 |  Mount Gould | 20 | 17 | 2 | 1 | 86 | 17 | 69 | 53 |
| 3 |  Plymstock United | 20 | 8 | 5 | 7 | 41 | 50 | -9 | 29 |
| 4 |  Lakeside Athletic | 20 | 8 | 4 | 8 | 58 | 60 | -2 | 28 |
| 5 |  Bere Alston United | 20 | 8 | 4 | 8 | 32 | 39 | -7 | 28 |
| 6 |  Plymouth Argyle Development | 20 | 7 | 6 | 7 | 42 | 40 | 2 | 27 |
| 7 |  Buckland Athletic Reserves | 20 | 8 | 3 | 9 | 30 | 46 | -16 | 27 |
| 8 |  Plympton Athletic | 20 | 5 | 4 | 11 | 37 | 54 | -17 | 19 |
| 9 |  Newton Abbot Spurs Reserves | 20 | 5 | 3 | 12 | 32 | 62 | -30 | 18 |
| 10 |  Paignton Saints | 20 | 5 | 1 | 14 | 36 | 76 | -40 | 16 |
| 11 |  Ipplepen Athletic | 20 | 5 | 0 | 15 | 39 | 70 | -31 | 15 |